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The neurocranium of hominid species has been largely studied with reference to the midsagittal plane, with variations being attributed to brain evolution. By contrast, there is limited information on variation in non-midsagittal regions, which are the points of insertion of muscles and bony structures related to mastication. This work aims to analyze ontogenetic changes and sexual dimorphism (SD) in midsagittal and non-midsagittal neurocranial structures from a contemporary human sample comprising 138 computed tomography (CT) cranial images of individuals ranging from infants to adults. Morphology of the vault and the base was assessed by registering landmarks and semilandmarks, which were analyzed by geometric morphometrics, and the endocranial volume (EV). The results of regressions and Kruskal-Wallis test indicate that the major size and shape changes in both midsagittal and non-midsagittal regions occur during infancy and juvenility; shape changes are also associated with an increase in EV. The size of the midsagittal vault, the shape of the non-midsagittal vault and the size of the base show an extension of ontogenetic trajectories. Sexes show similar changes in shape but different changes in size. We conclude that brain growth appears to be an important factor influencing the morphology of the neurocranium, at least during infancy and childhood. Subsequent changes may be attributed to osteogenic activity and the differential growth of the brain lobes. Masticatory-related bony structures and muscles may not be strong enough factors to induce independent modifications in non-midsagittal structures. The small influence of the cranial muscles would explain why the human neurocranium is a quite integrated structure. © 2018 E. Schweizerbart’sche Verlagsbuchhandlung, 70176 Stuttgart, Germany.


Documento: Artículo
Título:Complex pattern of variation in neurocranial ontogeny revealed by CT-scanning
Autor:Anzelmo, M.; Ventrice, F.; Kelmansky, D.; Sardi, M.
Filiación:División Antropología, CONICET, Museo de La Plata., Facultad de Ciencias Naturales y Museo., Universidad Nacional de La Plata. La Plata, Buenos Aires, 1900, Argentina
Hospital Posadas, Buenos Aires, Argentina
Instituto de Cálculo., Facultad de Ciencias Naturales y Exactas, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Development; Functional matrices; Growth; Modern human; Modularity; adolescent; adult; anatomy and histology; animal; brain; cephalometry; child; diagnostic imaging; female; growth, development and aging; human; infant; male; physical anthropology; preschool child; procedures; skull; x-ray computed tomography; young adult; Adolescent; Adult; Animals; Anthropology, Physical; Brain; Cephalometry; Child; Child, Preschool; Female; Humans; Infant; Male; Skull; Tomography, X-Ray Computed; Young Adult
Página de inicio:89
Página de fin:100
Título revista:Anthropologischer Anzeiger
Título revista abreviado:Anthropol. Anz.


  • Ackermann, R.R., Krovitz, G.E., Common patterns of facial ontogeny in the hominid lineage (2002) Anat. Rec., 269, pp. 142-147
  • Anzelmo, M., Sardi, M.L., Barbeito-Andrés, J., Pucciarelli, H.M., Alometrías ontogénicas y dimorfismo sexual facial en dos poblaciones humanas modernas (2012) Rev. Arg. Antrop. Biol., 14 (1), pp. 89-100
  • Anzelmo, M., Barbeito-Andrés, J., Ventrice, F., Pucciarelli, H.M., Sardi, M.L., Ontogenetic patterns of morphological variation in the ectocranial human vault (2013) Anat. Rec., 296, pp. 1008-1015
  • Anzelmo, M., Ventrice, F., Barbeito-Andres, J., Pucciarelli, H.M., Sardi, M.L., Ontogenetic changes in cranial vault thickness in a modern sample of Homo Sapiens (2014) Am. J. Hum. Biol., 27, pp. 475-485
  • Arnqvist, G., Martensson, T., Measurement error in geometric morphometrics: Empirical strategies to assess and reduce (1998) Acta Zool. Acad. Sci. Hung., 44, pp. 73-96
  • Balzeau, A., Are thickened cranial bones and equal participation of the three structural bone layers autapomorphic traits of Homo erectus? (2006) Bull. Mem. Soc. Anthrop. Paris, 18, pp. 145-163
  • Barbeito-Andrés, J., Ventrice, F., Anzelmo, M., Pucciarelli, H.M., Sardi, M.L., Developmental covariation of human vault and base throughout postnatal ontogeny (2015) Ann. Anat., 197, pp. 59-66
  • Bastir, M., Rosas, A., Hierarchical nature of morphological integration and modularity in the human posterior face (2005) Am. J. Phys. Anthropol., 128 (1), pp. 26-34
  • Bastir, M., Rosas, A., Correlated variation between the lateral basicranium and the face: A geometric morphometric study in different human groups (2006) Arch. Oral. Biol., 51 (9), pp. 814-824
  • Bastir, M., Rosas, A., Mosaic evolution, integration and modularity: Evolution of the human cranial base (2008) Am. J. Phys. Anthropol., S46, p. 65
  • Bastir, M., Rosas, A., Mosaic evolution of the basicranium in Homo and its relation to modular development (2009) Evol. Biol., 36 (1), pp. 57-70
  • Bastir, M., O’Higgins, P., Rosas, A., Human evolution: Relationships between the basicranium and the face (2005) Ann. Hum. Biol., 32, p. 790
  • Bastir, M., Rosas, A., O’Higgins, P., Craniofacial levels and the morphological maturation of the human skull (2006) J. Anat., 209, pp. 637-654
  • Bastir, M., Rosas, A., Lieberman, D.E., O’Higgins, P., Middle cranial fossa anatomy and the origins of modern humans (2008) Anat. Rec., 291 (2), pp. 130-140
  • Baughan, B., Demirjian, A., Sexual dimorphism in the growth of the cranium (1978) Am. J. Phys. Anthropol., 49 (3), pp. 383-390
  • Baughan, B., Demirjian, A., Levesque, G.Y., Lapalme-Chaput, L., The pattern of facial growth before and during puberty, as shown by French-Canadian girls (1979) Ann. Hum. Biol., 6, pp. 59-76
  • Bienvenu, T., Guy, F., Coudyzer, W., Gilissen, E., Roualdès, G., Vignaud, P., Brunet, M., Assessing endocranial variations in great apes and humans using 3D data from virtual endo-casts (2011) Am. J. Phys. Anthropol., 145, pp. 231-246
  • Bogin, B., (1999) Patterns of Human Growth, , Cambridge University Press, Cambridge
  • Bogin, B., The human pattern of growth and development in paleontological perspective (2003) Patterns of Growth and Development in The Genus Homo, pp. 15-44. , In: Thompson, J.L., Krovitz, G.E. & Nelson, A.J. (eds): – Cambridge University Press, Cambridge
  • Bookstein, F., Schafer, K., Prossinger, H., Seidler, H., Fieder, M., Stringer, C., Weber, G.W., Marcus, L.F., Comparing frontal cranial profiles in archaic and modern Homo by morphometric analysis (1999) Anat. Rec., 257, pp. 217-224
  • Bookstein, F., Gunz, P., Mitteroecker, P., Prossinger, H., Schaefer, K., Seidler, H., Cranial integration in Homo: Singular warps analysis of the midmidsagittal plane in ontogeny and evolution (2003) J. Hum. Evol., 44, pp. 167-187
  • Bruner, E., Saracino, B., Passarello, P., Ricci, F., Tafuri, M., Manzi, G., Midmidsagittal cranial shape variation in the genus Homo by geometric morphometrics (2004) Coll. Antropol., 28, pp. 99-112
  • Buikstra, J., Ubelaker, D., Standards for data collection from human skeletal remains (1994) Arkansas Archaeological Survey Research Series, 44. , Fayetteville
  • Bulygina, E., Mitteroecker, P., Aiello, L., Ontogeny of facial dimorphism and patterns of individual development within one human population (2006) Am. J. Phys. Anthropol., 131 (3), pp. 432-443
  • Buschang, P.H., Hinton, R.J., A gradient of potential for-modifying craniofacial growth (2005) Sem. Orthod., 11, pp. 219-226
  • Conroy, G.C., Weber, G.W., Seidler, H., Recheis, W., Zur Nedden, D., Mariam, J.H., Endocranial capacity of the Bodo cranium determined from three-dimensional computed tomography (2000) Am. J. Phys. Anthropol., 113, pp. 111-118
  • Enlow, D.H., (1990) Facial Growth, , WB Saunders, Philadelphia
  • Enlow, D.H., Hans, M.G., (1996) Essentials of Facial Growth, , WB Saunders, Philadelphia
  • Giedd, J.N., Lalonde, F.M., Celano, M.J., White, S.L., Wallace, G.L., Lee, N.R., Lenroot, R.K., Anatomical brain magnetic resonance imaging of typically developing children and adolescents (2009) J. Am. Acad. Child. Adolesc. Psychiat., 48 (5), pp. 465-470
  • Gogtay, N., Giedd, J.N., Lusk, L., Hayashi, K.M., Greenstein, D., Vaituzis, A.C., Nugent, T.F., III, Thompson, P.M., Dynamic mapping of human cortical development during childhood through early adulthood (2004) Proc. Natl. Acad. Sci. USA, 101 (21), pp. 8174-8179
  • González, P.N., Bernal, V., Perez, S.I., Analysis of sexual dimorphism of craniofacial traits using geometric morphometric techniques (2009) Int. J. Osteoarchaeol., 21, pp. 82-91
  • Guihard-Costa, A., Ramirez-Rozzi, F., Growth of the human brain and skull slows down at about 2.5 years old (2004) C. R. Palevol., 3, pp. 397-402
  • Gunz, P., Mitteroecker, P., Bookstein, F.L., Semilandmarks in three dimensions (2005) Modern Morphometrics in Physical Anthropology, pp. 73-98. , Slice, D.E. (ed): – Kluwer Academic/ Plenum Publishers, New York
  • Hallgrímsson, B., Lieberman, D.E., Liu, W., Hutchinson, A.F., Jirik, F.R., Epigenetic interactions and the structure of phenotypic variation in the cranium (2007) Evol. Dev., 9, pp. 76-91
  • Howells, W.W., Cranial Variation in Man. A Study by Multivariate Analysis of Patterns of Differences Among Recent Human Populations (1973) Papers Peabody Mus, 67, p. 259
  • Humphrey, L.T., Growth patterns in the modern human skeleton (1998) Am. J. Phys. Anthropol., 105, pp. 57-72
  • Imbelloni, J., Tabla clasificatoria de los indios regiones biológicas y grupos raciales humanos de América (1938) Physis, 12, pp. 229-249
  • Kendall, D.G., The diffusion of shape (1977) Adv. Appl. Prob., 9, pp. 428-430
  • Klingenberg, C.P., Quantitative genetics of geometric shape: Heritability and the pitfalls of the univariate approach (2003) Evol, 57, pp. 191-195
  • Klingenberg, C.P., Morphometric integration and modularity in configurations of landmarks: Tools for evaluating a priori hypotheses (2009) Evol. Dev., 11 (4), pp. 405-421
  • Klingenberg, C.P., Size, shape, and form: Concepts of allometry in geometric morphometrics (2016) Dev. Genes Evol., 226, pp. 113-137
  • Leigh, S.R., Cheverud, J.M., Sexual dimorphism in the baboon facial skeleton (1991) Am. J. Phys. Anthropol., 84 (2), pp. 193-208
  • Lenroot, R.K., Giedd, J.N., Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging (2006) Neurosci. Biobehav. Rev., 30 (6), pp. 718-729
  • Lieberman, D.E., Ross, C.F., Ravosa, M.J., The primate cranial base: Ontogeny, function, and integration (2000) Yb. Phys. Anthropol., 43, pp. 117-169
  • Lieberman, D.E., McBratney, B.M., Krovitz, G.E., The evolution and development of cranial form in Homo sapiens (2002) PNAS, 99 (3), pp. 1134-1139
  • Lieberman, D.E., Krovitz, G.E., Yates, F.W., Devlin, M., St Claire, M., Effects of food processing on masticatory strain and craniofacial growth in a retrognathic face (2004) J. Hum. Evol., 46 (6), pp. 655-677
  • Mitteroecker, P., Gunz, P., Bookstein, F.L., Heterochrony and geometric morphometrics: A comparison of cranial growth in Pan paniscus versus Pan troglodytes (2005) Evol. Dev., 7, pp. 244-258
  • Moss, M.L., Young, R.W., A functional approach to crani-ology (1960) Am. J. Phys. Anthropol., 18 (4), pp. 281-292
  • Neubauer, S., Gunz, P., Hublin, J.-J., The pattern of endocranial ontogenetic shape changes in humans (2009) J. Anat., 215 (3), pp. 240-255
  • Neubauer, S., Gunz, P., Hublin, J.-J., Endocranial shape changes during growth in chimpanzees and humans: A morphometric analysis of unique and shared aspects (2010) J. Hum. Evol., 59 (5), pp. 555-566
  • Opperman, L.A., Gakunga, P.T., Carlson, D.S., Genetic factors influencing morphogenesis and growth of sutures and synchondroses in the craniofacial complex (2005) Semin. Orthod., 11, pp. 199-208
  • Porto, A., Oliveira, F.B., Shirai, L.T., Conto, V., Marroig, G., The evolution of modularity in the mammalian skull I: Morphological integration patterns and magnitudes (2009) Evol. Biol., 36, pp. 118-135
  • Rawlinson, S.C.F., Mosley, J.R., Suswillo, R.F.L., Pitsillides, A.A., Lanyon, L.E., Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain (1995) J. Bone Min. Res., 10, pp. 1225-1232
  • Reddy, D.P., Harvati, K., Kim, J., An alternative approach to space curve analysis using the example of the Neanderthal occipital bun (2004) Modern Morphometrics in Physical Anthropology, pp. 99-115. , Slice, D.E. (ed.): – Kluwer Academic/Plenum Publishers, New York
  • Richtsmeier, J.T., Corner, B.D., Grausz, H.M., Cheverud, J.M., Danahey, S.E., The role of postnatal growth pattern in the production of facial morphology (1993) Syst. Biol., 42, pp. 307-330
  • Richtsmeier, J.T., Aldridge, K., DeLeon, V.B., Panchal, J., Kane, A.A., Marsh, J.L., Yan, P., Cole, T.M., Phenotypic integration of neurocranium and brain (2006) J. Exp. Zool. B. Mol. Dev. Evol., 306, pp. 360-378
  • Ricklan, D.E., Tobias, P.V., Unusually low sexual dimorphism of endocranial capacity in a Zulu cranial series (1986) Am. J. Phys. Anthropol., 71, pp. 285-293
  • Rosas, A., Bastir, M., Thin-plate spline analysis of allometry and sexual dimorphism in the human craniofacial complex (2002) Am. J. Phys. Anthropol., 117 (3), pp. 236-245
  • Rushton, J.P., Cranial capacity related to sex, rank, and race in a stratified random sample of 6,325 U.S. Military personnel (1992) Intelligence, 16, pp. 401-413
  • Sardi, M.L., Ramírez-Rozzi, F., A cross-sectional study of human craniofacial growth (2005) Ann. Hum. Biol., 32, pp. 390-396
  • Sardi, M.L., Ramírez-Rozzi, F., Developmental connections between cranial components and the emergence of the first permanent molar in humans (2007) J. Anat., 210, pp. 406-417
  • Sardi, M.L., Barbeito-Andrés, J., Ventrice, F., Ramírez-Rozzi, F., Anzelmo, M., Guihard-Costa, A.-M., Covariación ontogénica en el endocráneo de Pan troglodytes (2014) Rev. Arg. Antrop. Biol., 16 (2), pp. 79-91
  • Sperber, G.H., (2010) Craniofacial Development and Growth, , People Medical Publishing House, Shelton
  • Spoor, F., Jeffery, N., Zonneveld, F., Imaging skeletal growth and evolution (2000) Development, Growth and Evolution, pp. 123-161. , O’Higgins, (ed.): – The Linnaean Society of London, London
  • Strand-Vidarsdóttir, U., O’Higgins, P., Development of sexual dimorphism in the facial skeleton of anatomically modern Homo sapiens (2001) Am. J. Phys. Anthropol., 114, pp. 139-152
  • Strand-Vidarsdottir, U., O’Higgins, P., Stringer, C.B., A geometric morphometric study of regional differences in the growth of the modern human facial skeleton (2002) J. Anat., 201, pp. 211-229
  • Trinkaus, E., LeMay, M., Occipital bunning among later Pleistocene hominids (1982) Am. J. Phys. Anthropol., 57, pp. 27-35
  • Ventrice, F., Modern human brain growth and development (2011) Contribution to Brain Evolution in Hominins, , PhD Thesis. Universität Zürich, Zurich
  • Vieth, E., Fitting piecewise linear regression functions to biological responses (1989) J. App. Phys., 67, pp. 390-396
  • Zelditch, M., Swiderski, D.L., Shetts, H.D., Finks, W.L., (2004) Geometric Morphometrics for Biologists: A Primer, , Elsevier Academic Press, Amsterdam
  • Zollikofer, C.P.E., Bienvenu, T., Ponce de León, M.S., Effects of cranial integration on hominid endocranial shape (2016) J. Anat., 230, pp. 85-105


---------- APA ----------
Anzelmo, M., Ventrice, F., Kelmansky, D. & Sardi, M. (2018) . Complex pattern of variation in neurocranial ontogeny revealed by CT-scanning. Anthropologischer Anzeiger, 75(2), 89-100.
---------- CHICAGO ----------
Anzelmo, M., Ventrice, F., Kelmansky, D., Sardi, M. "Complex pattern of variation in neurocranial ontogeny revealed by CT-scanning" . Anthropologischer Anzeiger 75, no. 2 (2018) : 89-100.
---------- MLA ----------
Anzelmo, M., Ventrice, F., Kelmansky, D., Sardi, M. "Complex pattern of variation in neurocranial ontogeny revealed by CT-scanning" . Anthropologischer Anzeiger, vol. 75, no. 2, 2018, pp. 89-100.
---------- VANCOUVER ----------
Anzelmo, M., Ventrice, F., Kelmansky, D., Sardi, M. Complex pattern of variation in neurocranial ontogeny revealed by CT-scanning. Anthropol. Anz. 2018;75(2):89-100.