Abstract:
Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
Registro:
Documento: |
Artículo
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Título: | Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health |
Autor: | Newton, P.N.; Hampton, C.Y.; Alter-Hall, K.; Teerwarakulpana, T.; Prakongpan, S.; Ruangveerayuth, R.; White, N.J.; Day, N.P.J.; Tudino, M.B.; Mancuso, N.; Fernández, F.M. |
Filiación: | Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Laos School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, United States Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom Faculty of Pharmacy, Mahidol University, Bangkok, Thailand Mae Sot Hospital, Mae Sot, Tak Province, Thailand Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand Departamento de Química Inorgánica, Analítica Y Química Física, Instituto de Quimica de Los Materiales, Medio Ambiente Y Energia, Ciudad Universitaria, 1428, Buenos Aires, Argentina
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Palabras clave: | acetylsalicylic acid; alprenolol; amitriptyline; ampicillin; antacid agent; artemisinin; ascorbic acid; chloroquine; chlorpheniramine; diclofenac; dipyrone; doxycycline; indometacin; nicotinamide; paracetamol; prazepam; prednisolone; primaquine; pyridoxine; quinine; sulfamethoxazole; tetracycline; thiamine; tolperisone; acidosis; agranulocytosis; article; atomic absorption spectrometry; bradycardia; disease severity; drowsiness; drug capsule; drug efficacy; gastrointestinal irritation; health care cost; hemolysis; human; hypoglycemia; malaria; mass spectrometry; methemoglobinemia; morbidity; mortality; multidrug resistance; Myanmar; newborn hemolytic disease; Plasmodium falciparum; rash; stomach irritation; tablet; Thailand; tinnitus; Plasmodium falciparum |
Año: | 2008
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Volumen: | 79
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Número: | 5
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Página de inicio: | 662
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Página de fin: | 669
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Título revista: | American Journal of Tropical Medicine and Hygiene
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Título revista abreviado: | Am. J. Trop. Med. Hyg.
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ISSN: | 00029637
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CODEN: | AJTHA
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CAS: | acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; alprenolol, 13655-52-2, 13707-88-5, 39405-98-6, 58615-82-0; amitriptyline, 50-48-6, 549-18-8; ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0; artemisinin, 63968-64-9; ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; chlorpheniramine, 132-22-9; diclofenac, 15307-79-6, 15307-86-5; dipyrone, 50567-35-6, 5907-38-0, 68-89-3; doxycycline, 10592-13-9, 17086-28-1, 564-25-0, 94088-85-4; indometacin, 53-86-1, 74252-25-8, 7681-54-1; nicotinamide, 11032-50-1, 98-92-0; paracetamol, 103-90-2; prazepam, 2955-38-6; prednisolone, 50-24-8; primaquine, 90-34-6; pyridoxine, 12001-77-3, 58-56-0, 65-23-6, 8059-24-3; quinine, 130-89-2, 130-95-0, 14358-44-2, 549-48-4, 549-49-5, 60-93-5, 7549-43-1; sulfamethoxazole, 723-46-6; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; thiamine, 59-43-8, 67-03-8; tolperisone, 3644-61-9, 728-88-1
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00029637_v79_n5_p662_Newton |
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Citas:
---------- APA ----------
Newton, P.N., Hampton, C.Y., Alter-Hall, K., Teerwarakulpana, T., Prakongpan, S., Ruangveerayuth, R., White, N.J.,..., Fernández, F.M.
(2008)
. Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health. American Journal of Tropical Medicine and Hygiene, 79(5), 662-669.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00029637_v79_n5_p662_Newton [ ]
---------- CHICAGO ----------
Newton, P.N., Hampton, C.Y., Alter-Hall, K., Teerwarakulpana, T., Prakongpan, S., Ruangveerayuth, R., et al.
"Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health"
. American Journal of Tropical Medicine and Hygiene 79, no. 5
(2008) : 662-669.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00029637_v79_n5_p662_Newton [ ]
---------- MLA ----------
Newton, P.N., Hampton, C.Y., Alter-Hall, K., Teerwarakulpana, T., Prakongpan, S., Ruangveerayuth, R., et al.
"Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health"
. American Journal of Tropical Medicine and Hygiene, vol. 79, no. 5, 2008, pp. 662-669.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00029637_v79_n5_p662_Newton [ ]
---------- VANCOUVER ----------
Newton, P.N., Hampton, C.Y., Alter-Hall, K., Teerwarakulpana, T., Prakongpan, S., Ruangveerayuth, R., et al. Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health. Am. J. Trop. Med. Hyg. 2008;79(5):662-669.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00029637_v79_n5_p662_Newton [ ]