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Pensel, P.E.; Ullio Gamboa, G.; Fabbri, J.; Ceballos, L.; Sanchez Bruni, S.; Alvarez, L.I.; Allemandi, D.; Benoit, J.P.; Palma, S.D.; Elissondo, M.C. "Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice" (2015) Acta Tropica. 152:185-194
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Abstract:

Therapeutic failures attributed to medical management of cystic echinococcosis (CE) with albendazole (ABZ) have been primarily linked to the poor drug absorption rate resulting in low drug level in plasma and hydatid cysts. Lipid nanocapsules (LNCs) represent nanocarriers designed to encapsulate lipophilic drugs, such as ABZ. The goals of the current work were: (i) to characterize the plasma and cyst drug exposure after the administration of ABZ as ABZ-LNCs or ABZ suspension (ABZ-SUSP) in mice infected with Echinococcus granulosus, and ii) to compare the clinical efficacies of both ABZ formulations. Enhanced ABZ sulphoxide (ABZ-SO) concentration profiles were obtained in plasma and cysts from ABZ-LNC treated animals. ABZSO exposure (AUC0-LOQ) was significantly higher in plasma and cyst after the ABZ-LNC treatments, both orally and subcutaneously, compared to that observed after oral administration of ABZ-SUSP. Additionally, ABZSO concentrations measured in cysts from ABZ-LNC treated mice were 1.7-fold higher than those detected in plasma. This enhanced drug availability correlated with an increased efficacy against secondary CE in mice observed for the ABZ-LNCs, while ABZ-SUSP did not reach differences with the untreated control group. This new pharmacotechnically-based strategy could be a potential alternative to improve the treatment of human CE. © 2015 Elsevier B.V.

Registro:

Documento: Artículo
Título:Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice
Autor:Pensel, P.E.; Ullio Gamboa, G.; Fabbri, J.; Ceballos, L.; Sanchez Bruni, S.; Alvarez, L.I.; Allemandi, D.; Benoit, J.P.; Palma, S.D.; Elissondo, M.C.
Filiación:Laboratorio de Zoonosis Parasitaria, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, Mar del Plata, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, UNITEFA-CONICET, Ciudad Universitaria, Córdoba, Argentina
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina
LUNAM Université, Université d'Angers, INSERM U1066, IBS-CHU Angers, 4 rue Larrey, Angers, France
Palabras clave:Albendazole; Cystic echinococcosis; Echinococcus granulosus; Lipid nanocapsules; albendazole; lipid nanocapsule; nanocapsule; unclassified drug; albendazole; anthelmintic agent; lipid; bioavailability; concentration (composition); drug; lipid; medical geography; parasitic disease; rodent; animal experiment; animal model; area under the curve; Article; controlled study; drug bioavailability; drug blood level; drug dosage form comparison; drug efficacy; drug exposure; drug formulation; echinococcosis; female; in vitro study; maximum plasma concentration; mouse; nanoencapsulation; nonhuman; time to maximum plasma concentration; animal; bioavailability; drug delivery system; echinococcosis; Echinococcus granulosus; medicinal chemistry; oral drug administration; Animalia; Echinococcus granulosus; Mus; Administration, Oral; Albendazole; Animals; Anthelmintics; Biological Availability; Chemistry, Pharmaceutical; Drug Delivery Systems; Echinococcosis; Echinococcus granulosus; Female; Lipids; Mice; Nanocapsules
Año:2015
Volumen:152
Página de inicio:185
Página de fin:194
DOI: http://dx.doi.org/10.1016/j.actatropica.2015.09.016
Título revista:Acta Tropica
Título revista abreviado:Acta Trop.
ISSN:0001706X
CODEN:ACTRA
CAS:albendazole, 54965-21-8; lipid, 66455-18-3; Albendazole; Anthelmintics; Lipids; Nanocapsules
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0001706X_v152_n_p185_Pensel

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Citas:

---------- APA ----------
Pensel, P.E., Ullio Gamboa, G., Fabbri, J., Ceballos, L., Sanchez Bruni, S., Alvarez, L.I., Allemandi, D.,..., Elissondo, M.C. (2015) . Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. Acta Tropica, 152, 185-194.
http://dx.doi.org/10.1016/j.actatropica.2015.09.016
---------- CHICAGO ----------
Pensel, P.E., Ullio Gamboa, G., Fabbri, J., Ceballos, L., Sanchez Bruni, S., Alvarez, L.I., et al. "Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice" . Acta Tropica 152 (2015) : 185-194.
http://dx.doi.org/10.1016/j.actatropica.2015.09.016
---------- MLA ----------
Pensel, P.E., Ullio Gamboa, G., Fabbri, J., Ceballos, L., Sanchez Bruni, S., Alvarez, L.I., et al. "Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice" . Acta Tropica, vol. 152, 2015, pp. 185-194.
http://dx.doi.org/10.1016/j.actatropica.2015.09.016
---------- VANCOUVER ----------
Pensel, P.E., Ullio Gamboa, G., Fabbri, J., Ceballos, L., Sanchez Bruni, S., Alvarez, L.I., et al. Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. Acta Trop. 2015;152:185-194.
http://dx.doi.org/10.1016/j.actatropica.2015.09.016