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Abstract:

Recent brain functional magnetic resonance imaging (fMRI) studies have shown that chronic back pain (CBP) alters brain dynamics beyond the feeling of pain. In particular, the response of the brain default mode network (DMN) during an attention task was found abnormal. In the present work similar alterations are demonstrated for spontaneous resting patterns of fMRI brain activity over a population of CBP patients (n= 12, 29-67 years old, mean = 51.2). Results show abnormal correlations of three out of four highly connected sites of the DMN with bilateral insular cortex and regions in the middle frontal gyrus (p< 0.05), in comparison with a control group of healthy subjects (n= 20, 21-60 years old, mean = 38.4). The alterations were confirmed by the calculation of triggered averages, which demonstrated increased coactivation of the DMN and the former regions. These findings demonstrate that CBP disrupts normal activity in the DMN even during the brain resting state, highlighting the impact of enduring pain over brain structure and function. © 2010 Elsevier Ireland Ltd.

Registro:

Documento: Artículo
Título:Brain resting state is disrupted in chronic back pain patients
Autor:Tagliazucchi, E.; Balenzuela, P.; Fraiman, D.; Chialvo, D.R.
Filiación:Dept. de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Argentina
Dept. de Matemática y Ciencias, Universidad de San Andrés, Buenos Aires, Argentina
Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina
Department of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States
Palabras clave:Brain; Chronic pain; Default mode network; FMRI; Functional connectivity; Resting state networks; adult; aged; article; backache; brain function; chronic pain; clinical article; controlled study; functional magnetic resonance imaging; human; insula; nervous system parameters; pain threshold; priority journal; rest; Adult; Aged; Back Pain; Brain; Brain Mapping; Case-Control Studies; Chronic Disease; Humans; Magnetic Resonance Imaging; Middle Aged; Oxygen; Rest
Año:2010
Volumen:485
Número:1
Página de inicio:26
Página de fin:31
DOI: http://dx.doi.org/10.1016/j.neulet.2010.08.053
Título revista:Neuroscience Letters
Título revista abreviado:Neurosci. Lett.
ISSN:03043940
CODEN:NELED
CAS:Oxygen, 7782-44-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v485_n1_p26_Tagliazucchi

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Citas:

---------- APA ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D. & Chialvo, D.R. (2010) . Brain resting state is disrupted in chronic back pain patients. Neuroscience Letters, 485(1), 26-31.
http://dx.doi.org/10.1016/j.neulet.2010.08.053
---------- CHICAGO ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Chialvo, D.R. "Brain resting state is disrupted in chronic back pain patients" . Neuroscience Letters 485, no. 1 (2010) : 26-31.
http://dx.doi.org/10.1016/j.neulet.2010.08.053
---------- MLA ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Chialvo, D.R. "Brain resting state is disrupted in chronic back pain patients" . Neuroscience Letters, vol. 485, no. 1, 2010, pp. 26-31.
http://dx.doi.org/10.1016/j.neulet.2010.08.053
---------- VANCOUVER ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Chialvo, D.R. Brain resting state is disrupted in chronic back pain patients. Neurosci. Lett. 2010;485(1):26-31.
http://dx.doi.org/10.1016/j.neulet.2010.08.053