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antineoplastic agent

"Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry" (2018) Pertino, M.W.; Petrera, E.; Edith Alché, L.; Schmeda-Hirschmann, G. Molecules. 23(6)

"Selective hemangioma cell dysfunction and apoptosis triggered by in vitro treatment with imiquimod" (2018) Rocco, R.;Alegre, N.;Pozner, R. (...)Gazzaniga, S. Toxicology Letters. 288:82-88

"Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys" (2018) Abiuso, A.M.B.;Varela, M.L.;Haro Durand, L. (...)Mondillo, C. European Journal of Cancer. 91:125-135

"A Minimalist Approach to the Design of Complexity-Enriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents" (2018) Alonso, F.;Quezada, M.J.;Gola, G.F. (...)Ramírez, J.A. ChemMedChem. 13(16):1732-1740

"Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode" (2017) Maglietti, F.;Tellado, M.;Olaiz, N. (...)Marshall, G. Radiology and Oncology. 51(4):422-430

"Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model" (2017) Marostica, L.L.;de Barros, A.L.B.;Oliveira, J. (...)Simões, C.M.O. Toxicology and Applied Pharmacology. 329:272-281

"Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl D-ribofuranosides" (2017) Avanzo, R.E.; Padrón, J.M.; D'Accorso, N.B.; Fascio, M.L. Bioorganic and Medicinal Chemistry Letters. 27(16):3674-3677

"Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go?" (2017) Sun, W.;Thiramanas, R.;Slep, L.D. (...)Wu, S. Chemistry - A European Journal. 23(45):10832-10837

"Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells" (2017) Basso, A.V.;Leiva González, S.;Barboza, G.E. (...)Nicotra, V.E. Chemistry and Biodiversity. 14(8)

"Synthesis and cytotoxicity evaluation of A-ring derivatives of cycloartanone" (2017) Zambrano, E.E.;Casas, A.G.;Di Venosa, G.M. (...)Palermo, J.A. Phytochemistry Letters. 21:200-205

"In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B" (2015) Silva, I.T.;Carvalho, A.;Lang, K.L. (...)Ludwig, S. PLoS ONE. 10(2)

"Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes" (2015) Rebuzzini, P.;Cebral, E.;Fassina, L. (...)Garagna, S. Scientific Reports. 5

"Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties" (2015) Fascio, M.L.; Errea, M.I.; D'Accorso, N.B. European journal of medicinal chemistry. 90:666-683

"Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties" (2015) Fascio, M.L.; Errea, M.I.; D'Accorso, N.B. European Journal of Medicinal Chemistry. 90:666-683

"Low doses of CPS49 and flavopiridol combination as potential treatment for advanced prostate cancer" (2015) Zalazar, F.;De Luca, P.;Gardner, K. (...)De Siervi, A. Current Pharmaceutical Biotechnology. 16(6):553-563

"Synergistic Antiproliferative Effects of a New Cucurbitacin B Derivative and Chemotherapy Drugs on Lung Cancer Cell Line A549" (2015) Marostica, L.L.;Silva, I.T.;Kratz, J.M. (...)Simões, C.M.O. Chemical Research in Toxicology. 28(10):1949-1960

"Human MageB2 protein expression enhances E2F transcriptional activity, cell proliferation, and resistance to ribotoxic stress" (2015) Peche, L.Y.;Ladelfa, M.F.;Toledo, M.F. (...)Monte, M. Journal of Biological Chemistry. 290(49):29652-29662

"Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases" (2014) Wan, X.;Corn, P.G.;Yang, J. (...)Navone, N.M. Science Translational Medicine. 6(252)

"Differential effect of heterocyclic d-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression" (2014) Gueron, G.;Avanzo, R.E.;Schuster, F. (...)D'Accorso, N.B. Biomedicine and Pharmacotherapy. 68(7):847-854

"The rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy" (2014) Orqueda, A.J.;Dansey, M.V.;Español, A. (...)Pecci, A. Biochemical Pharmacology. 89(4):526-535

"QSAR on antiproliferative naphthoquinones based on a conformation- independent approach" (2014) Duchowicz, P.R.;Bennardi, D.O.;Bacelo, D.E. (...)Misico, R.I. European Journal of Medicinal Chemistry. 77:176-184

"Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines" (2014) Cardama, G.A.;Comin, M.J.;Hornos, L. (...)Menna, P.L. Anti-Cancer Agents in Medicinal Chemistry. 14(6):840-851

"Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia" (2014) Rocha-Viegas, L.;Villa, R.;Gutierrez, A. (...)Croce, L.D. Molecular and Cellular Biology. 34(19):3765-3775

"Agarofuran sesquiterpenes from Schaefferia argentinensis" (2013) García, M.E.;Motrich, R.D.;Caputto, B.L. (...)Nicotra, V.E. Phytochemistry. 94:260-267

"Vascular galectins: Regulators of tumor progression and targets for cancer therapy" (2013) Thijssen, V.L.; Rabinovich, G.A.; Griffioen, A.W. Cytokine and Growth Factor Reviews. 24(6):547-558

"Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas" (2013) Curic, S.;Wu, Y.;Shan, B. (...)Renner, U. Journal of Neuro-Oncology. 113(3):385-396

"1,2,4-Triazole d-ribose derivatives: Design, synthesis and antitumoral evaluation" (2012) Avanzo, R.E.;Anesini, C.;Fascio, M.L. (...)D'Accorso, N.B. European Journal of Medicinal Chemistry. 47(1):104-110

"β-Lapachone analogs with enhanced antiproliferative activity" (2012) Ríos-Luci, C.;Bonifazi, E.L.;León, L.G. (...)Padrón, J.M. European Journal of Medicinal Chemistry. 53:264-274

"Key questions in metastasis: New insights in molecular pathways and therapeutic implications" (2011) Gueron, G.; de Siervi, A.; Vazquez, E. Current Pharmaceutical Biotechnology. 12(11):1867-1880

"FKBP51 and FKBP52 in signaling and disease" (2011) Storer, C.L.;Dickey, C.A.;Galigniana, M.D. (...)Cox, M.B. Trends in Endocrinology and Metabolism. 22(12):481-490

"Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa" (2010) De Almeida, M.T.R.; Ríos-Luci, C.; Padrón, J.M.; Palermo, J.A. Phytochemistry. 71(14-15):1741-1748

"Cytotoxic terpenoids from Nardophyllum bryoides" (2010) Sánchez, M.;Mazzuca, M.;Veloso, M.J. (...)Palermo, J.A. Phytochemistry. 71(11-12):1395-1399

"Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation" (2010) Lavaggi, M.L.;Cabrera, M.;Aravena, M.d.l.A. (...)Cerecetto, H. Bioorganic and Medicinal Chemistry. 18(12):4433-4440

"Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog" (2009) Careaga, V.P.;Bueno, C.;Muniain, C. (...)Maier, M.S. Chemotherapy. 55(1):60-68

"Invasive giant prolactinoma with loss of therapeutic response to cabergoline: Expression of angiogenic markers" (2009) Mallea-Gil, M.S.;Cristina, C.;Perez-Millan, M.I. (...)Becu-Villalobos, D. Endocrine Pathology. 20(1):35-40

"Endogenous and exogenous porphyrins as photosensitizers in the Hep-2 human carcinoma cell line" (2009) Alvarez, M.G.;Milanesio, M.;Rivarola, V. (...)Fukuda, H. Cellular and Molecular Biology. 55(2):8-14

"Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support" (2008) Trelles, J.A.;Bentancor, L.;Grasselli, M. (...)Iribarren, A.M. Journal of Molecular Catalysis B: Enzymatic. 52-53(1-4):189-193

"Nucleoside phosphorylases" (2006) Lewkowicz, E.S.; Iribarren, A.M. Current Organic Chemistry. 10(11):1197-1215

"Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum" (2004) Riveiro, M.E.;Shayo, C.;Monczor, F. (...)Davio, C. Cancer Letters. 210(2):179-188

"New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides." (2003) Rodríguez, J.B.; Comin, M.J. Mini reviews in medicinal chemistry. 3(2):95-114

"p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells" (2002) Martinez, L.A.;Yang, J.;Vazquez, E.S. (...)Navone, N.M. Carcinogenesis. 23(8):1289-1296

"Preparation and cytotoxicity toward cancer cells of mono(arylimino) derivatives of β-lapachone" (2001) Di Chenna, P.H.;Benedetti-Doctorovich, V.;Baggio, R.F. (...)Burton, G. Journal of Medicinal Chemistry. 44(15):2486-2489

"On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice" (2001) Caballero, F.;Gerez, E.;Oliveri, L. (...)Vazquez, E. International Journal of Biochemistry and Cell Biology. 33(7):681-690

"Eruptive lesions in a patient with bone marrow transplantation" (2001) Marini, M.;Saponaro, A.;Remorino, L. (...)Magariños, G. International Journal of Dermatology. 40(2):133-135

"Paesslerins A and B: Novel Tricyclic Sesquiterpenoids from the Soft Coral Alcyonium Paessleri" (2001) Rodríguez Brasco, M.F.; Seldes, A.M.; Palermo, J.A. Organic Letters. 3(10):1415-1417

"Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters" (2000) Palermo, J.A.; Brasco, M.F.R.; Spagnuolo, C.; Seldes, A.M. Journal of Organic Chemistry. 65(15):4482-4486

"Reactivity of monoclonal antibody FC-2.15 against drug resistant breast cancer cells. Additive cytotoxicity of adriamycin and taxol with FC-2.15" (1998) Ballaré, C.;Portela, P.;Schiaffi, J. (...)Mordoh, J. Breast Cancer Research and Treatment. 47(2):163-170

"Evaluation of the porphyrinogenic risk of antineoplastics" (1997) Cochón, A.C.; Aldonatti, C.; San Martín De Viale, L.C.; De Calmanovici, R.W. Journal of Applied Toxicology. 17(3):171-177

"Synthetic oligonucleotides and their application in gene therapy " (1995) Iribarren, A.M. Medicina. 55(3):263-266

"Recent developments in the control of Trypanosoma cruzi, the causative agent for Chagas' disease" (1995) Rodriguez, J.B.; Gros, E.G. Current Medicinal Chemistry. 2(3):723-742

"Effect of sulfation on the biological activity of β-(1→3)-glucans from the tree fungus Cyttaria harioti Fischer" (1989) Fernandez Cirelli, A.;Covian, J.A.;Ohno, N. (...)Yadomae, T. Carbohydrate Research. 190(2):329-337

"Effect of some antineoplasics on metabolic heme pathway" (1988) Wainstok De Calmanovici, R.; San Martin De Viale, L.C. International Journal of Biochemistry. 20(9):1015-1020